Physical inactivity: common pathway to peripheral muscle weakness in chronic respiratory diseases?

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Physical inactivity: common pathway to peripheral muscle weakness in chronic respiratory diseases?

L ower limb muscle atrophy and weakness are common in patients with chronic obstructive pulmonary disease (COPD) and make an important contribution to limiting their exercise tolerance [1]. Muscle disuse, hypoxaemia, malnutrition, oxidative stress and systemic inflammation have all been portrayed as possible causes of muscle dysfunction in COPD [2]. As far as systemic inflammation is concerned,...

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ژورنال

عنوان ژورنال: European Respiratory Journal

سال: 2009

ISSN: 0903-1936,1399-3003

DOI: 10.1183/09031936.00092409